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Table of contents
- Literature review fibrinolysis in 2021
- Fibrinolysis therapy
- Fibrinolysis disorders
- Primary fibrinolysis
- Secondary fibrinolysis
- Fibrinolysis slideshare
- Fibrinolytic enzymes
- Fibrinolysis mechanism
Literature review fibrinolysis in 2021
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Fibrinolysis therapy
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Fibrinolysis disorders
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Primary fibrinolysis
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Secondary fibrinolysis
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Fibrinolysis slideshare
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Fibrinolytic enzymes
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Fibrinolysis mechanism
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What are the basic mechanisms and regulation of fibrinolysis?
This brief review covers selected aspects of fibrinolysis with a focus on recent developments that improve our understanding of regulation. Space does not allow for many important historic citations which are replaced by reference to more recent reviews and apologies are given to original authors.
How are fibrin fiber diameter and clot architecture related?
Fibrin fiber diameter and clot architecture influence fibrinolysis, so clot stability and resistance is predetermined to a significant degree at the clot formation stage. This brief review covers selected aspects of fibrinolysis with a focus on recent developments that improve our understanding of regulation.
How does fibrin degradation lead to aggregate formation?
Fibrin degradation leads to aggregate formation to focus the binding of tPA (via finger domain) and plasminogen (at C-terminal lysines) around amyloid-like cross-β structures to complete fibrinolysis through a series of fibrin degradation products, culminating in DDE the smallest FDP to bind tPA and plasminogen.
How is thioflavin T ( THT ) used in fibrinolysis?
Panel C shows the staining of fibrin aggregates by thioflavin T (ThT) after 45 min of fibrinolysis with native (unlabeled) tPA. ThT fluorescence indicates the presence of amyloid-like cross-β structures, which are able to bind the finger domain of tPA (images adapted from 13 ).
Last Update: Oct 2021